GREMMLENZ UNICAMP

This study presents the synthesis of two novel metal complexes of penicillamine (Pen) with the molecular formulas [Ag(C5H10O2NS)]·H2O and [Au(C5H10O2NS)]. These complexes were synthesized by reacting the ligand with silver nitrate and potassium dicyanoaurate(I) salts in aqueous solutions. Analytical characterizations included elemental (C, H, N, and S), thermal (TG-DTA), and electrospray ionization mass spectrometry (ESI-MS) analyses. Solid-state 13C nuclear magnetic resonance (SSNMR) and infrared (IR) spectroscopic measurements indicated the coordination of Pen to Ag(I) or Au(I) through the sulfur atom. Density functional theory (DFT) studies confirmed Pen as an S-donor ligand to Au(I) or Ag(I).

Thermal decompositions of the silver(I) and gold(I) complexes commenced at temperatures near 50 °C, resulting in the formation of Ag0 and Au0 at 700 °C and 500 °C, respectively. Both complexes exhibit limited solubility in common solvents such as water, methanol, ethanol, acetonitrile, hexane, and dimethylsulfoxide. An antibiogram assay, performed using the disc diffusion method, revealed antibacterial activities of the AgPen complex against Escherichia coli and Pseudomonas aeruginosa bacterial strains.

Explore the synthesis, spectroscopic characterization, and antibacterial properties of these intriguing silver(I) and gold(I) complexes with penicillamine.

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