GREMMLENZ UNICAMP

Raphael E. F. de Paiva, Camilla Abbehausen, Fernando R. G. Bergamini, Andre L. Thompson, Danilo A. Alves, Marcelo Lancellotti & Pedro P. Corbi

This study unveils the preparation and characterization of inclusion systems involving β-cyclodextrin (β-CD) and the silver(I) nimesulide coordination complex (Ag-NMS), employing kneading (K) and co-evaporation (CE) methods. Solid-state characterization through Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), and Infrared (IR) vibrational spectroscopy provides compelling evidence of genuine inclusion system formation. Solution measurements shed light on the inclusion mode.

UV–Vis spectroscopy, employing the Scatchard method, reveals association constants, with a noteworthy value of 370 ± 2 L mol−1. 1H Nuclear Magnetic Resonance (NMR) spectroscopic analyses indicate complete inclusion of the guest into the cavity. A 2D NOESY experiment for the inclusion complex demonstrates clear correlations between hydrogens 3–6 of the cyclodextrin and the protons of the phenoxy ring of nimesulide in the Ag-NMS coordination compound, confirming inclusion complex formation.

The antibacterial activities of the Ag-NMS and CE-[(Ag-NMS)·β-CD] inclusion system were assessed against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacterial strains using the well diffusion method. Results indicate significant antibacterial activity for the Ag-NMS coordination complex, while the inclusion complex shows no activity under the considered conditions.

Explore the intricacies of Ag(I)-Nimesulide β-CD inclusion systems, from their solid-state characteristics to their antibacterial efficacy against pathogenic bacterial strains.

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