GREMMLENZ UNICAMP

Embark on a journey through the fascinating realm of Metallodrugs, where cutting-edge research converges with the development of innovative metal-based compounds with diverse applications.

Our explorations span a spectrum of compounds, each contributing to the ever-evolving landscape of medicinal chemistry.

Discover the potential of Gold(I) compounds, where the effects of coordination modes of 2-mercaptothiazoline on reactivity with thiols and sulfur-containing proteins are meticulously investigated. Uncover the complexities of ligand substitution in linear Gold(I) compounds, with ligands such as PR3 and CN− dictating substitution reactions and influencing the coordination mode of the 2-mercaptothiazoline ligand.

Journey into the world of Crystal Structures and Cytotoxic Activities, where a bis(pyrrolyl-imine) Gold(III) complex takes center stage. This complex, synthesized with N,N′-ethylenebis(pyrrol-2-yl-methyleneamine), undergoes thorough physicochemical and spectroscopic characterization. Dive into the density functional theory (DFT) studies and cytotoxic assays that shed light on its potential in medical applications.

Explore the Synthesis, Structural Characterization, and Antibacterial Assays of Silver Sulfadoxinate, unraveling the formation of a new Silver(I) complex through the reaction of sulfadoxine with Ag+ ions. Witness the structural intricacies revealed by chemical, spectroscopic, and unconventional X-ray powder diffraction analyses. Delve into its limited solubility and antibacterial properties against Gram-positive and Gram-negative bacterial strains.

Venture into the realm of Inclusion Complexes, where the Ag(I)-nimesulide complex finds its place within β-cyclodextrin. Solid-state and solution studies showcase the intriguing association constants and the total inclusion of the guest into the cavity. Antibacterial activities against pathogenic bacterial strains add a layer of significance to this inclusion complex.

Immerse yourself in the Biological Activity and Specific Interactions of Gold(I)-Phosphine-N-Heterocycles on the C-Terminal HIVNCp7 Zinc Finger. Synthesized linear triphenylphosphine Gold(I) complexes with substituted N-heterocycle ligands undergo thorough characterization. Witness the systematic variations influencing carrier groups and leaving groups, shedding light on their cytotoxicity, cell cycle signaling effects, and cellular accumulation.

Unveil the Silver(I) and Gold(I) Complexes with Penicillamine, where novel metal complexes are synthesized and characterized. Explore their limited solubility, thermal decompositions, and antibacterial activities against both Gram-positive and Gram-negative bacterial strains.